Mucolytics like Pulmozyme are used by CF patients to thin the mucus in the lungs, and make it easier to cough it out (cff.org). The CFF website says:
Pulmozyme acts like “scissors” in the mucus. It cuts up the DNA strands outside the cell that can make CF mucus thick and sticky. This DNA is from the white blood cells that work to fight lung infections. Even if a person with CF has not had a lung infection, the white blood cell DNA is still in the mucus (cff.org).
Like hypertonic saline and albuterol, this is another nebulized medicine that I often hear other CF parents talk about. Judith is not on it yet (nor is she on hypertonic saline), so our experience with both this and hypertonic saline is limited.